LEFLUNOMIDE (Arava) is the first isoxazol derivative approved for the treatment of rheumatoid arthritis. Leflunomide was also the first agent for rheumatoid arthritis indicated for both symptomatic improvement and retardation of structural joint damage based on radiographic evidence of its disease modifying activity.
A generic drug (pl. generic drugs, short: generics) is a drug which is produced and distributed without patent protection. A generic must contain the same active ingredients as the original formulation. In most cases, it is considered bioequivalent to the brand name counterpart with respect to pharmacokinetic and pharmacodynamic properties. By extension, therefore, generics are assumed to be identical in dose, strength, route of administration, safety, efficacy, and intended use.
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